11/5/2023 0 Comments Vmd measure center![]() ![]() Overall, our simulations reveal complex relationships between the rich lipid composition of the HIV-1 liposome and its structural, mechanical and dynamical properties with critical consequences to different stages of HIV-1’s life cycle.Įnveloped viruses are molecular pathogens enclosed in a lipid bilayer acquired from the host cell during viral assembly and egress. Finally, dynamical properties of the lipid molecules reveal important relationships between their 3D diffusion, the location of lipid-rafts and the asymmetrical composition of the envelope. Moreover, full-scale mechanical analyses are employed to derive the global bending rigidity of HIV-1 liposomes. Analysis of the structural properties reveal the distribution of thicknesses of the bilayers over the entire liposome as well as its global fluctuations. ![]() ![]() Here, molecular dynamics (MD) simulations of authentic, asymmetric HIV-1 liposomes are used to derive a unique level of resolution of its full-scale structure, mechanics and dynamics. Thus, the composition of the bilayer depends on the complex constitution of lipids from the host-cell’s organelle(s) where assembly and/or budding of the viral particle occurs. The envelope is derived from the host cell during viral replication. Viral envelopes are lipid bilayers that adopt morphologies ranging from spheres to tubes. Enveloped viruses are enclosed by a lipid membrane inside of which are all of the components necessary for the virus life cycle viral proteins, the viral genome and metabolites. ![]()
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